"Compromise makes a good umbrella but a poor roof"
Compromise is a dangerous thing. Yes it is nice for an insta-fix. Seldom do compromises make for a permanent fix. Think of a compromise as a bandaid. Bandaids are great for scraps and scratches. Bandaids, however, are ineffective for a gaping wound. They may help but not nearly enough to help the healing process. Don't bandaid your novel. If you feel the story will suffer so greatly it wouldn't be complete then don't compromise on the edit. Now I'm not suggesting you be unwise and disregard the request of your agent or editor. But if you reach an impass, why not shelf that novel until another time instead of compromising & making the novel something its not.