<Make big plans, but change your plans as time changes>
Welp. We're done here. Time to go back to your regularly scheduled programming. (kidding) Time changes a lot of things. Things that time changes, changes how we view time.
Maybe you've wanted to be published traditionally but hear the same thing from agents, this topic is dead (e.g. shape shifters, vampires, dystopian), but are confident that your manuscript is so shiny you could blind a pilot at thirty thousand feet then explore self-publishing. Times have changed and technology is progressing quickly. Along with that new avenues have opened for us, writers, to utilize. There are dozens of sites to self-pub.